GLP-1 receptor agonists, such as semaglutide, tirzepatide. and liraglutide, have become widely used in weight management and diabetes care, offering benefits like blood sugar regulation, appetite control, and weight loss support. These medications have helped many individuals achieve significant health improvements, but they can also contribute to nutrient depletion over time.
Since GLP-1 medications work by slowing gastric emptying and reducing hunger, many patients experience lower food intake and altered digestion. This can lead to deficiencies in essential vitamins and minerals, which are crucial for energy, muscle function, bone health, and overall well-being. Understanding how these medications affect nutrient levels and taking steps to replenish any deficiencies is essential for maintaining long-term health while using GLP-1 therapy.
Key Nutrients Affected by GLP-1 Medications & How to Supplement
Long-term use of GLP-1 receptor agonists may impact the absorption and retention of key nutrients. Consult with one of the pharmacists at Westmoreland Pharmacy to help tailor a personalized supplement regimen to support overall health while on GLP-1 therapy. Our pharmacy only carries professional-grade nutritional supplements to ensure that you are receiving quality products for optimal outcomes. Below are some of the most commonly affected nutrients and recommended supplements to help prevent deficiencies:
Vitamin B12 & Folate
- Why It’s Important: Vitamin B12 and folate play a key role in energy production, red blood cell formation, and nerve function. Deficiencies can lead to fatigue, brain fog, numbness or tingling in extremities, and anemia.
- Why GLP-1s May Deplete It: Reduced food intake and altered digestion can limit B12 and folate absorption, especially in individuals with already low levels.
- Recommended Supplementation: Methylated B12 (Methylcobalamin) and Folate (L-Methylfolate)
INTEGRATIVE THERAPEUTICS PRODUCTS:
- B-12 Active
- Active B-Complex
Magnesium
- Why It’s Important: Magnesium supports muscle function, nerve signaling, blood sugar balance, and heart health. Deficiency can lead to muscle cramps, irritability, poor sleep, and fatigue.
- Why GLP-1s May Deplete It: Decreased food intake may limit magnesium intake, and some diabetes medications (like metformin) further reduce magnesium levels.
- Recommended Supplementation: Magnesium Glycinate or Magnesium Malate
INTEGRATIVE THERAPEUTICS PRODUCTS:
- Krebs magnesium-potassium complex
- Magnesium glycinate plus
- Magnesium malate
- Tri-magnesium
Coenzyme Q10 (CoQ10)
- Why It’s Important: CoQ10 is essential for cellular energy production, cardiovascular health, and antioxidant activity that may help protect the body against free radicals and support blood sugar control. Low levels can contribute to fatigue, muscle weakness, and heart health concerns.
- Why GLP-1s May Deplete It: Individuals using GLP-1s for diabetes management may experience lower CoQ10 levels, especially if they are also taking statins, which have been shown to further deplete CoQ10.
- Recommended Supplementation: Ubiquinol (the active form of CoQ10) which may help support energy production and heart health.
INTEGRATIVE THERAPEUTICS PRODUCTS:
- CoQ10
- UBQH
Probiotics
- Why It’s Important: A healthy gut microbiome supports digestion, immune function, and nutrient absorption. An imbalance can lead to digestive discomfort, bloating, and poor absorption of key nutrients.
- Why GLP-1s May Deplete It: GLP-1 medications alter gut motility, which may disrupt the natural balance of gut bacteria.
- Recommended Supplementation: A high-quality multi-strain probiotic to help maintain gut health and support digestion.
INTEGRATIVE THERAPEUTICS PRODUCTS:
- Enterogenic Intensive 100
- Pro-Biome
FLORAJEN
Vitamin D & Calcium
- Why It’s Important: These nutrients are crucial for bone strength, immune health, and muscle function. Low levels may contribute to bone loss, increased risk of fractures, and muscle weakness.
- Why GLP-1s May Deplete It: Reduced food intake may decrease dietary calcium consumption, while vitamin D is often deficient in many adults regardless of medication use.
- Recommended Supplementation: Vitamin D3 + K2 to enhance calcium absorption and maintain bone health.
INTEGRATIVE THERAPEUTICS PRODUCTS:
- K2 + D3
- Vitamin D3 (50mcg and 125mcg)
- Liquid Calcium Magnesium
Additional Considerations for GLP-1 Users
While supplementation is a key strategy for helping to maintain nutrient balance, lifestyle habits also play an essential role. Here are a few additional steps to ensure optimal health while using GLP-1 medications:
- Eat Nutrient-Dense Foods – Even with a reduced appetite, prioritize lean proteins, healthy fats, fiber-rich vegetables, and whole grains to maintain essential nutrient levels.
- Monitor Symptoms – Be aware of signs of nutrient deficiencies, such as fatigue, dizziness, muscle weakness, numbness, digestive issues, or hair thinning. These may indicate a need for targeted supplementation.
- Stay Hydrated – Many GLP-1 users experience reduced thirst, increasing the risk of dehydration. Ensure adequate water and electrolyte intake throughout the day.
- Stay Active – Incorporate physical activity, including strength training, into your routine to help build and maintain muscle mass.
GLP-1 receptor agonists have shown significant benefits for weight management and diabetes care, but it is important to address potential nutrient depletions to maintain overall health and well-being. By incorporating targeted supplements, a nutrient-rich diet, and professional guidance, individuals using GLP-1 medications can optimize their results while preventing deficiencies.
INTEGRATIVE THERAPEUTICS PRODUCTS:
- Clinical Nutrients – a high-potency, once-daily multivitamin designed to provide comprehensive nutritional support for both men and women.
For personalized supplement recommendations or customized formulations, our team is here to help. Contact us today to learn more about how to maintain proper nutrition while on GLP-1 therapy. Our high quality supplements are available in our New Albany location or you can purchase online in our FullScript online store. https://us.fullscript.com/welcome/westmoreland/store-start
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
